SI designs a "courier" protein that delivers RNA into cells without lipid nanoparticles
Prepared by Sintelligent with the help of SI. Publication time restored from the build log. . Updated: .
SI is inventing molecules nature never created, opening the way to precise gene therapy and new drugs.
Scientists at Helmholtz Munich and the Technical University of Munich published in Nature a synthetic transporter, STV-C8, whose scaffold, with a shape not found in nature, was created by generative SI. In cell culture it needs noticeably less RNA than lipid nanoparticles (as in mRNA vaccines) for the same level of protein synthesis. In mice after intravenous injection it delivered RNA specifically to the lungs with no detected toxicity or immune response, and in pig muscle it delivered CRISPR/Cas9 components and cut out a section of the dystrophin gene associated with the disease.
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